Lessons from treatment resistant hyperlipidaemia

Lessons from treatment resistant hyperlipidaemia

A 68-year-old woman was referred to Lipid Clinic with sudden deterioration of previously well-controlled primary hyperlipidaemia. Investigations revealed nephrotic range proteinuria, leading to urgent renal biopsy and a diagnosis of amyloidosis. Chemotherapy was successful in stabilising renal function, reducing proteinuria and eliminating serum paraprotein. The resistant hyperlipidaemia subseq...

Drug treatment of hyperlipidaemia--a controversy.

Partial lipoatrophy with insulin resistant diabetes and hyperlipidaemia (Dunnigan syndrome).

A family is presented in which at least five members in three generations suffered a characteristic syndrome of generalised lipoatrophy, sparing the head and neck, and muscle hypertrophy variably associated with high plasma insulin and lipid levels and insulin resistant diabetes. This pedigree contains the first documented affected male with the syndrome. The diagnosis is of practical importanc...

DORADO: opportunity postponed: lessons from studies of endothelin receptor antagonists in treatment-resistant hypertension.

Treatment-resistant hypertension (TRH) describes a situation where blood pressure (BP) remains above target in spite of the concurrent use of 3 antihypertensive agents of different classes, with 1 of the agents a diuretic, and all ideally given at an optimized dose. TRH is a common clinical problem, perhaps occurring in 20% to 30% of participants in hypertension trials, and is likely to become ...

Scaling-up treatment for HIV/AIDS: lessons learned from multidrug-resistant tuberculosis.

The UN has launched an initiative to place 3 million people in developing countries on antiretroviral AIDS treatment by end 2005 (the 3 by 5 target). Lessons for HIV/AIDS treatment scale-up emerge from recent experience with multidrug-resistant tuberculosis. Expansion of treatment for multidrug-resistant tuberculosis through the multipartner mechanism known as the Green Light Committee (GLC) ha...